Members of the DAN Family Are BMP Antagonists That Form Highly Stable Noncovalent Dimers
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چکیده
منابع مشابه
All four members of the Ten-m/Odz family of transmembrane proteins form dimers.
Ten-m/Odz/teneurins are a new family of four distinct type II transmembrane molecules. Their extracellular domains are composed of an array of eight consecutive EGF modules followed by a large globular domain. Two of the eight modules contain only 5 instead of the typical 6 cysteine residues and have the capability to dimerize in a covalent, disulfide-linked fashion. The structural properties o...
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The Dan family of transforming growth factor beta antagonists is a large, evolutionarily conserved family of proteins. Little is known about either the specificity of these antagonists or the biological roles of these proteins. We have characterized Dan, the founding member of this family, with regard to both its biochemical specificity and its biological roles. Although DAN is not an efficient...
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Members of the Bone morphogenetic protein (BMP) family have been shown to be important signaling molecules throughout mouse development. Accordingly, many BMPs are also expressed during organogenesis of the metanephric kidney. However, only BMP7 has been shown to be absolutely required for proper formation of the kidney, thus the majority of information known involves this family member. BMP7 i...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2012
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2012.10.003